There is life with HIV

Is the 60-day HIV immune window reliable?

Rapid fourth generation HIV test, 30 to 60 days reliable? Is this immune window enough?

Image Credit to IgorVetushko - Portfolio Igor Vetushko

Immune Window - Facts: What is HIV?

Is 30 to 60 day immune window reliable? The 4th generation test is reliable, can I rest assured? What is the immune window period for HIV testing? I have been answering this question for many years and now I have new data that I need to publish. Read, reason and understand. If you need to, talk to me.

We are here to help!

What is HIV?

HIV means human immunodeficiency virus. HIV is the virus that can lead to AIDS / AIDS acquired immunodeficiency syndrome which, if not treated correctly ...

Unlike other viruses, the human body cannot completely get rid of HIV, even with treatment. So, since you contract HIV, you will carry it throughout your life.

HIV attacks the body's immune system, specifically CD4 cells (T cells), which help the immune system fight infections.


What are the symptoms of HIV?

There are several symptoms of HIV. Not everyone will have the same symptoms. It depends on the person and the stage of the disease they are in.
How I Have HIV I Went Through Stage 1: Acute HIV Infection

Within 2 to 4 weeks after becoming infected with HIV, about two-thirds of people will have a flu-like illness. This is the body's natural response to HIV infection.

Flu-like symptoms can include:
These symptoms can last from a few days to several weeks. But some people don't have any symptoms during this early stage of HIV.
Don't Assume! HIV, or AIDS, is not, is not and has never been punishment. Certain religious people say these things. But not the Christ!
Don't assume that you have HIV just because you have one of these symptoms. They are similar to those of almost all viruses. However, if you believe you may have been exposed to HIV, get tested.
Do not freak out! Freak out doesn't get you anywhere

Here's what to do:

Find an HIV testing site near you—You can get an HIV test at your primary care provider's office, your local health department, a health clinic, or many other places. Use the HIV Service Finder to find an HIV testing site near you.
Order an HIV test for recent infection - most HIV tests detect antibodies (proteins your body makes in response to HIV), not HIV itself. But it can take a few weeks after the infection for your body to produce them. Other categories of tests can detect HIV infection earlier. Tell your doctor or clinic if you think you have recently been exposed to HIV. And ask before use if their tests can detect infection early.
Know your status- after taking the test, make sure you know the test results. If you are HIV positive, see a doctor as soon as possible so that you can start treatment with HIV drugs. And be aware: when you are in the early stages of infection, you are at a very high risk of transmitting HIV to others. It is important to take steps to reduce the risk of transmission. There are prevention tools like a condom (a condom), pre-exposure prophylaxis (PrEP.) that can help you stay negative, or PEP, which is a medical emergency!
Stage 2: Clinical Latency

At this stage of clinical latency, the virus still multiplies, but at very low levels. People at this stage may not feel sick or have any symptoms. This stage is also called chronic HIV infection.

Without HIV treatment, people can stay in this phase for 10 or 15 years, but some go through this phase more quickly.

If you take HIV medicine every day, exactly as prescribed, achieve and maintain an undetectable viral load, you protect your health and lower the risk of transmitting HIV to your sexual partner(s).

But if your viral load is detectable, it's easier to transmit HIV even when there are no symptoms. It is important to see your doctor regularly to check your viral load. Therapeutic vacation is almost suicide.

Here is something clear, the symptoms of HIV are not those of this Stage 3: AIDS


Do HIV Symptoms Mean I Have HIV?

HIV symptoms are very, extremely generic. Don't go from the impression of having these symptoms to the definitive statement: I have HIV

HIV infection is a possibility if you have had unprotected sex, if you use injecting drugs sharing vestments, but this needs to be proven with a test.

It is a frightening possibility, I know, this of having become a person living with HIV. That is why it is important to know the answer to this question:

Do I have HIV?

A
The only way to know for sure if you have HIV is to get tested. You cannot rely on apparent HIV symptoms to know if you are a carrier of the virus.

Knowing your HIV status provides important information so that you can take steps to keep you and your partner (s) healthy:

If your test is positive, you can, and should, take medicine to treat HIV. By taking your HIV medication as prescribed, your viral load will decrease. To the point where no test detects the presence of HIV, the viral load is undetectable.
It is the best thing you can do to stay healthy.
Having an undetectable viral load makes it difficult to transmit the virus.
If your test is negative, there are prevention tools other than condoms available today more than ever.

People read about symptoms of HIV and confuse them with symptoms of AIDS.

And the distance that exists between these two realities exists even in the calendar.

The path, the natural path of the evolution of the disease, HIV infection, and its symptoms, is very different from everything you usually believe. Believing this myself, at a time when I was looking for death, I let myself be deceived, and ended up contracting HIV because I believed it would be this:

"Shovel, and ball"! No, it is not.

HIV symptoms and AIDS signs ARE NOT THE SAME! You can read part of my mistake here, in this very clear statement where I say that, for me, I don't think about healing, given my mistakes.


If you are pregnant and believe you may have HIV!

If you are pregnant, you should be tested for HIV so that you can start treatment if you are HIV positive. If an HIV-positive woman is treated for HIV in early pregnancy. it decreases the risk of transmitting HIV to the baby.

The State of São Paulo was, in Brazil, the first State to eradicate Vertical transmission. And Santos, the first city in the country. The text continues after the video, but the video is very important for you and your baby!

HIV self-testing is also an option. HIV self-testing allows people to take an HIV test at home or another private location. You can buy a kit from a drugstore. Your doctor can give you one if you have one. Some health departments or community organizations also provide kits free of charge.


Psychosomatics is Science! not crazy

The Sad Suffering of Those Who Live in Fear of Somatizations

I'm not crazy / crazy! And it is impossible to sum up this thing! I have read so much about somatization that when I realize a problem I put it on the list of things to note and it is not uncommon for it to be a summation You, those who follow me more closely see me in a very wrong way . I AM ALSO AFRAID! And I just don't piss in fear at times because the bathroom is very close to the room. Everything can be summed up and, I believe, maybe even death and, from here in my chair, from a patient who reads and studies, in the eagerness to write and guide, I wonder if catalepsy, as well as narcolepsy, are not resulting processes somatization. I remember, as a child, knowing the death of an actor, he was a very dear actor, and his death was so overwhelming that the cast decided to pay a tribute on TV, and I can't say if it was live , and they also decided to end the novel. Later on, this actor, I don't know why, had to be exhumed and was found face down on the casket. Such is my fear of such a thing that I decided to be cremated! This is one of my fears and I have a long line of them. For example: When I am cremated will I awaken and taste the horrors of death in this way, burned alive? This is one of the greatest fears, but I do not lack others, and I will not verbalize them so as not to spread a wave of fear in you!

Somatizations! This Is Not Madness!

This is a short text where I talk about the people who suffer most from life with HIV. Those who did not contract it, but believe so, and live on somatizations, insisting that they are realities. later in this text, an interesting link leads to a text by a scholar in this field. Returning to those who come to me in fear of wrong tests, they see the symptoms of the disease in the most common organic manifestations of life, in which we rarely pay attention or we notice, purely and simply because we believe they contracted it, HIV. Some suffer with guilt. Others are afraid, although I'm not sure what, besides HIV itself. Others feel that HIV is a kind of "punishment". And to these, those who see HIV as such, as punishment, I ask: What is the most deplorable thing that has been done for this punishment? If you say that the person is like that or roasted and that he lives in the wrong way, I invite you to read this text, to see that the path itself is often beyond winding, narrow and dark!

Is Cancer a Punishment?

Would cancer, then, be more of a punishment? I have something to say about that. Ten years ago, maybe more, a person tried to get a notebook for me with a person who made huge donations to people with cancer. She asked for the notebook for me and the person said - "AIDS is a disease that can be prevented"! And I tell you: Cancer too! Good thoughts and good deeds can. Note that HIV, CANCER and any pathology are severely linked to cause and effect laws. Laws that spiritualists know well and, thus, it is quite true, certain things, including HIV, cannot be avoided!

An Aerodynamic Brake

And, I say this: for me, HIV, for me, served as an emergency brake! I was out of control for a long time and I would end up murdered if nothing was done! I could not count here how many homes and families I have destroyed and, thus, HIV has been a blessing for me. This blessing that changed me, actually helped me to become what I am now.

Someone that many people like and, if they knew me as I was, they would only harbor contempt for me HIV came to me with the aim of improving me and, in fact, that's what it did. Never a punishment.

Never, never and never a punishment. And I'm telling you this so that you, who found yourself with HIV, for you to observe the path that led you to this room, where we are now together, whether we like it or not.

The Almost Contracted. The almost, understand, I won't let


Dr. Drauzio Varella is a top person, he was an eyewitness to the arrival of AIDS in Brazil

Dr Drausio Varela is one of the doctors and personalities I most respect in the current Republic of Bananagua!

I notice an outbreak of people fearing folliculitis as an indicator of the presence of HIV in their bloodstream. And that fits into that other way of thinking where the person finds out (…) that person “X” can or could be living as an HIV carrier and has an outbreak.

He goes into despair.

Folliculitis and Immune Window have a not very close relationship and should not be your greatest source of doubt and fear. HIV would manifest itself in other, much more forceful ways! You have to accept science and medicine. Don't get carried away by everything they say and write. Pay attention, reason, think and see life as it really is!

Below is a brief introduction to the text of the Dr Drioio Varela website. I immediately notice that the text is longer, with good coverage and the necessary fonts. I appreciate the understanding of the DV Staff, I greet you respectfully, I thank you for the information! Hopefully it can reach many anguished people

Folliculitis is the name given to the acute or chronic inflammation of the hair follicles, a complex structure formed in tiny recesses in the skin, where the hairs are born and grow.

Hair follicles are spread throughout the human body, except for the palms of the hands, soles of the feet and the transition areas between the skin and mucous membranes, such as the lips, for example.

Although it can occur anywhere on the body where there is hair, the regions most vulnerable to the appearance of lesions are the face, scalp, armpits, thighs, buttocks and groins.

Mild inflammatory conditions may evolve favorably with basic hygiene care.

The most serious ones can lead to permanent hair loss and permanent scarring.

Any of us may experience episodes of folliculitis at some point in life. However, black, Asian, obese or people with low immunity are more likely to develop the disease. 


Is the 30-day immune window reliable? Yes. But there may be errors in that. There are crucial points to understand.

If you need to fully understand the answer to the eternal question: “Is a 30-day immune window reliable”, then you need to consider these factors as crucial!

Modern HIV tests can detect most infections within a month of exposure.
They can detect almost all infections in two months.
Fourth-generation lab tests have shorter window periods than rapid tests and self-tests.

Is 30 to 60 day immune window reliable? Yes, but you need to be aware of a number of details and please keep in mind that SUS testing and doctors are reliable, brands may vary, but methods, reagents, non-reactives and, unfortunately, undetermined results for HIV tests are, in short, all the same, with identical methodologies. Try to keep in mind that it is always the same antibodies, specific to the same virus, that we are looking for in these tests.

So you don't need to go from one CTA to another for new and repeated tests. An unnecessary drama and, let's face it, the country is very, very poorly run when it comes to health and, unfortunately6e, resources are scarce and dwindling. Porconaro doesn't care (wrath).

The epidemic of a new psychological condition, or even a bigger problem, with a dangerous psychiatric background, still emerging, which has shown me many things. And, among them, the immense ignorance and complete misinformation regarding the HIV epidemic. What makes me sure that, as much as I want to stop and feel exhausted, I can't stop with Blog Seropositive.

Do I intend to consider myself so important? Maybe, but the idea of ​​being necessary and useful does me good.

Even when I feel the knife in my throat

The other thing is sexual dogma. We are still the same and we live like our parents, Belchior drew well.

There is also a dangerous and false notion that HIV / AIDS, or any other condition, smells like punishment.

Read this:

If it was just me, I wouldn't care.
But I have my wife, pregnant, and my daughter “in her belly”!
I f *** me!

Is that prejudice or not? Tell me yourself! Well, I see it like this:

The person who tells me that, thinks, of me, exactly that: that I'm a rascal (not to write what I really thought), that I deserve what I'm going through and that, yes, I f**k myself!

This is not a recent photo…


How long are the immunological window periods of different HIV tests?

It is difficult to say exactly how long the window period lasts, as there are variations between individuals and it is a difficult topic to research, newly infected people would need to know exactly when they were exposed to HIV and then provide several blood samples during the following days and weeks. . Thus, if the 30-day Immune Window is reliable, it will always depend on other factors!

However, a study by Dr. Kevin Delaney and colleagues calculated window periods for a series of HIV tests.

All of these analyzes were based on plasma samples. Window periods tend to be several days longer when testing samples of finger-prick blood or oral fluid, as would be normal when using rapid tests at points of care and self-testing devices. Unfortunately, accurate figures for how long window periods are have not yet been published.

The researchers' analysis confirms that fourth-generation laboratory tests (which detect both antibodies and the p24 antigen) detect HIV infections between one and three weeks before the oldest antibody-only tests. In addition, their data suggest that guidelines in some countries that recommend a new test 90 days after possible exposure to HIV are more cautious than they should be.


A fourth generation laboratory test is recommended in UK and US guidelines as well as Brazil.

It uses a plasma or blood serum sample and can detect immunoglobulin G (IgG) antibodies, immunoglobulin M (IgM) antibodies, and p24 viral antigen (a protein contained in the viral core of HIV that can be detected before antibodies). Commonly used tests of this type include Abbott Architect HIV Ag/Ab, GS Combo Ag/Ab EIA, and Siemens Combo HIV Ag-Ab.

The average window period is 18 days (interquartile range 13 to 24 days). This indicates that half of all infections would be detected between 13 and 24 days after exposure.
99% of HIV-infected individuals would be detectable within 44 days of exposure.

A fourth generation rapid test is available (Determine HIV-1/2 Ag / Ab Combo). Although the results of this assay when testing plasma were broadly similar to equivalent laboratory tests, the window period will likely be several days longer when testing blood by fingerstick (on your finger), as the test is commonly used.


Pay attention The Immune Window period is Medium and Yes, the immune window of 30 is reliable, but in some cases, it may be subject to errors!

But not the temporal catastrophes of years and years. these cases may even exist, but they are infinitesimal rarities.

Some third-generation rapid on-site tests are available. They can detect both immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies. Examples include the INSTI HIV-1 / HIV-2 and Uni-Gold Recombigen HIV tests. The estimated window period for INSTI when testing plasma is as follows:

The average window period is 26 days (interquartile range 22 to 31 days). This indicates that half of all infections would be detected between 22 and 31 days after exposure.
99% of HIV-infected individuals would be detectable within 50 days of exposure.

"A negative result in a fourth generation test carried out four weeks after exposure is very likely to exclude HIV infection."

The immunological window period will probably be several days longer!

However, these estimates were based on plasma tests. In practice, tests are usually done on fingerstick blood and the window period will likely be several days longer.


However, these estimates were based on plasma tests. In practice, tests are usually done on finger-prick blood or oral fluid and the window period is likely to be several days longer.

Be Aware: 99% of HIV-infected individuals would be detectable within 57 days of exposure.
Many quick and immediate tests are described as second generation. They can detect immunoglobulin G (IgG) antibodies but not immunoglobulin M (IgM) antibodies or p24 viral antigen.

As these two substances are detectable before HIV infection than IgG antibodies, second-generation tests have longer window periods. Examples include OraQuick Advance Rapid HIV 1/2, Clearview HIV 1/2 STAT-PACK and SURE CHECK HIV 1/2.

The average window period is 31 days (interquartile range from 26 to 37 days). This indicates that half of all infections would be detected between 26 and 37 days after exposure.
99% of HIV-infected individuals would be detectable within 57 days of exposure.

However, these estimates were based on plasma tests. In practice, tests are usually done on finger-prick blood or oral fluid and the window period is likely to be several days longer.


Pay Lots, Lots of Attention: Self Test Devices and Immune Window

No self-test devices were included in this study.

However, most self-tests are modified versions of quick and spot test kits that were originally developed for healthcare professionals. Most are based on second-generation tests, so they are likely to have relatively long window periods.

Some, including those in the INSTI HIV self-test, are based on a third-generation test.

Likewise, self-testing was not included.

In the UK, this usually involves sending a blood sample from a finger prick to be tested in a laboratory with a fourth-generation antibody/antigen test. Plasma is extracted from the sample by centrifugation.

In theory, the test will be just as accurate with plasma from a self-collected fingerstick blood sample as with venous blood, including with regard to acute (recent) infection.


Immunological Window and Scientific Texts. Are these numbers always accurate?

In some situations, these numbers should be interpreted with caution:

When testing is done with blood samples from the finger or oral fluid (instead of blood plasma), the window periods are likely to be longer.
Individuals on pre-exposure prophylaxis (PrEP) or post-exposure prophylaxis (PEP) may have a delayed antibody response, extending the window period.
The data are based on individuals with HIV-1 subtype B (the form of HIV most commonly found in Western countries) and it is possible that the tests are less sensitive to other subtypes.


References

ReferencesBritish Association for Sexual Health and HIV. BASHH / EAGA Statement on the HIV Window Period, 2014.

Delaney KP et al. Time to onset of HIV test reactivity after HIV-1 infection: implications for the interpretation of test results and retesting after exposure. Clinical Infectious Diseases 64: 53-59, 2017.

Delaney KP et al. Time from HIV infection to earliest detection for 4 FDA-approved point-of-care tests. Conference on Retroviruses and Opportunistic Infections, abstract 565, 2018.


An important video if you are pregnant


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