There is life with HIV

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How “elite controllers can reveal the genetic key to HIV and establish a cure!

It is just the graphic reproduction of human cells. From the earliest days of my HIV infection I have heard of these elite controllers and I see their dendritic cells as a prospector dreams of "El Dorado." It will be, my God, that even I, who, for the most part, do not think about healing (I fear that healing will lead me to a process of loss of identity) will one day have the gratifying happiness of announcing, hand, "the AIDS Cure? I hope so. And I'm afraid not. Peripheral neuropathy has done havoc, and has been very effective in making them, which I come to fear for the worse, which is not death but the literal incapacitation even to this work I do basically out of love ... Will it will I have conditions? Will be? Will be? Will be....

It is a question involved in a lot of mystery and hope: Why do some people with HIV never become sick?

Research published on Thursday in the medical journal PLOS pathogens offers more clues to join the puzzle that could one day lead to an answer - and even a cure or an AIDS vaccine.

Scientists at Massachusetts General Hospital and the Ragon Institute looked at what happens when HIV infects the dendritic cells of people with HIV and whose infections never progress and never become sick. These people are known as "elite controllers."

Research shows that dendritic cells, in particular, play a key role in building the successful immune response to HIV.

I think of dendritic cells, as computer hardware for the body - they come as standard in everyone. Likewise, imagine T cells as software installed on each of us, doing the job of killing viruses. Without the hardware (dendritic cells) working properly, the software (T cells) is unable to load and function properly.

Dendritic cells "run" to the scene of infections. They patrol our bodies like a police against infection. When there are problems at the site, they intrude and pass on information about the infection to the T cells (CD4), which we often think are the cells that do the most difficult task: stop the disease.

What they found was that for most people, dendritic cells have the power to immediately block HIV infection and maintain it without being able to reproduce. This may sound like good news, but in reality, dendritic cells have really done their job when it does. In doing so, the dendritic cells express proteins necessary so that ultimately a light shines for the T cells, or CD 8 “killer” and CD4 “helper”, the cells that then come after the virus . Dendritic cells do not kill the virus completely, so it continues to disseminate and replicate throughout the body the information needed to clear the infection or, at least, to keep it under control, which in most cases is not done by the immune system.

But elite control dendritic cells are capable of actually stopping the virus because they lack a certain protein called SAMDH1 that would initially have the function of blocking viral replication. In doing so, dendritic cells can then sound the invasion alert, expressing themselves through a protein called cGAS, alerting T cells so that they can recognize HIV as a present invader and to mount an immune response. powerful .

“We are now focusing on fully understanding all the components needed to trigger dendritic cell activation during HIV infection, which can help induce a response by elite drug-independent controllers - the remission of HIV in a population broader number of patients, ”explained Dr. Xu Yu. Yu is an associate professor of medicine at Harvard Medical School.

The Ragon Institute is made up of scientists trained at Massachusetts General Hospital, MIT and Harvard.

To read the Massachusetts General Hospital press release on the research,  click here. To examine the real scientific role, click here.

By: David Heitz

June 11th, 2015

Translated by Cláudio Santos de Souza from the original in:

 HOW "ELITE CONTROLLERS" MAY HOLD THE GENETIC KEY TO AN HIV CURE on 14 July 2015

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