CHIV life cycle. Well, understanding this life cycle, the life cycle of a virus, HIV, which threatens our very life, was and still is an important aspect of our fight against it.
Well, look, HIV is the virus that causes “human immunodeficiency”! And it is worth clarifying that this puts me, after a time between five and twelve years, which may seem a lot, but it is not, in a condition of immunological vulnerability. This vulnerability exposes you to diseases that make COVID-19 a child's toy, just read about Pneumocystosis
By understanding these processes, we use the technique of disturbing these “moments in the cycle of HIV replication“. and buy time. Time is an invaluable currency when fighting for life and that is what it is about. To buy time.
Time to live.
Understanding the HIV Life Cycle
Understanding the HIV lifecycle made it possible to develop medicines we use to treat the disease, the HIV infection itself! Every time the virus replicated It allows us to identify how the virus makes copies of itself, which, as far as it is concerned, allows us to develop ways of blocking, or simply inhibiting, such a process, and with inhibition. Or the slowing down of this process, gaining, I repeat, some time. And in this fight against HIV infection, time is all we need to win. So: you take your antiretrovirals for the first time and having done this, with correction, you have started your fight, your battle for life and, depending on your medication schedule, you will have to take your medications in eight hours, or twelve hours
With each new tactic developed by us to disturb a certain process within all of this, we come to life! If we learn to disturb a particular process in two ways, when he learns how to get rid of one, he still encounters two obstacles, and in the meantime, we have time to develop other processes. Annoyances to him.
And there's no need read the Sun Tzu to know that!
Understand a little about opportunistic diseases:
Opportunistic diseases, flu, I need to clarify, is not one of them, so it is not necessary to fear it; opportunistic diseases are AIDS related and/or related or defining diseases, which in Portuguese or Spanish should be treated as AIDS, "Acquired immunodeficiency syndrome.
Two or three weeks ago when there was a fascinating event! This after they were finished at five hours I spent in the basement of a hospital, examined by "scintigraphy". It should be said that this is nuclear medicine, and that justifies being in the fourth basement.
Well, it was after all this that, slowly coming back I captured it, because that is my very nature of this fragment of a telephone conversation (or camera, I do not even know).
This fragment contained this expression:
Seven are the known processes in the HIV Life Cycle,
The reproductive cycle of the AIDS virus, which needs to be fought, stopped, so that it cannot make copies of itself and, in this way, move us from a simple case of HIV infection to a much more complicated case of AIDS , acquired immunodeficiency syndrome, this The life cycle of the AIDS virus is typically divided into 7 distinct stages, from the attachment of the virus to the host cell to the budding of new, free-flowing HIV virions.(photo). The steps are described in sequential orders as follows:
- Linking and merging
- Transcription and translation
- Maturation and budding
Disrupt any stage of the life cycle and the next cannot occur, making it impossible for the virus to multiply and spread.
This way, you keep your viral load undetectable, therefore, just for you, the idea of having a relationship without a condom with a person who does not have HIV can be valid and acceptable!
Provided, of course, you let her know, tim-tim by tim-tim about it. It doesn't work for me!
This stops the progressive increase in viral load. It gives time for the immune system to hunt and kill all the viral particles in “freedom” in the bloodstream; thus preventing them from invade other cells, because that is what it is about, and to enslave them, because it is also about that, preventing them from working for HIV until death, because it is also about that, and so it is very clear why I hate it! Never! Never feel hate for anything!
Once HIV enters the body (typically through sexual contact, blood exposure or mother-to-child transmission), it looks for a host cell to reproduce. The host in this case is the CD4 T cell used to signal an immune defense.
To infect the cell, HIV must be trapped by means of a lock-and-key system. Keys are proteins on the surface of HIV that bind to a courtesy protein in the CD4 cell much in the way a key fits into a lock. This is what is known as Viral attachment.
Viral attachment can be blocked by an inhibitor-class drug called Selzentry (Maraviroc).
One of my cousins considers the chain of things and factors that involve the name of this medicine fantastic!
- "Crazy"! She says.
Binding and Merging
Once connected to the cell, HIV injects its own proteins in the cellular fluids (cytoplasm) of the T cell. This causes a fusion of the cell membrane to the outer envelope of the HIV virion. This is the stage known as viral fusion. Once fused, the virus You are able to enter the cell.
An injectable HIV drug called Fuzeon (enfuvirtide) is capable of interfering with viral fusion.
HIV uses its genetic material (RNA) to reproduce by hijacking the host cell's genetic machine. In doing so, he can produce multiple copies of himself. The process, called viral peeling, requires that the protective coating around the RNA must be dissolved. Without this step, the conversion of RNA to DNA (the building blocks of a new virus) cannot take place.
Transcription and Translation
And so, once in the cell, RNA from a single strand of HIV must be converted to double-stranded DNA. It does this with the help of the enzyme called reverse transcriptase.
For reverse transcription uses T cell building blocks to literally transcribe the genetic material in reverse.
From RNA to DNA and explain to enslaved cell how to perform certain tasks.
For this is how RNA, once converted to DNA, that the genetic machinery has the necessary coding to conduct viral replication!
It is our body working against you. Understand and hate it. But don't hate it!
Drugs called reverse transcriptase inhibitors can block this process completely. Three drug categories, nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide transcriptase inhibitors (NtRTIs), and non-nucleoside reverse transcriptase inhibitors (NNRTIs), contain defective mimics of proteins that insert into developing DNA. By doing this, the double-stranded DNA strand cannot be fully formed, and replication is blocked.
Ziagen (abacavir), Sustiva (efavirenz), Viread (tenofovir) and Pifeltro (doravirine) are just some of the reverse transcriptase inhibitors commonly used for treating HIV.
Integration of HIV VIRAL RNA into Human Cell DNA
For HIV to hijack the host cell's genetic machines, it must integrate the newly formed DNA into the cell's nucleus. Drugs called integrase inhibitors are highly capable of blocking the stage of integration blocking the integrase enzyme used to transfer genetic material.
Isentress (raltegravir), Tivicay (dolutegravir) and Vitekta (elvitegravir) are three commonly prescribed integrase inhibitors.
Once integration has taken place, HIV must manufacture building blocks of proteins that it uses to assemble new viruses. It does this with the protease enzyme, which cuts protein into smaller pieces and then joins the pieces into new, fully formed hiv virions. A class of drugs called protease inhibitors can effectively block the assembly process.
Maturation and Budding the Final Part of the HIV Life Cycle
One of the virions are mounted, they go through the final stage when mature virions literally sprout from the infected host cell. Once released into free circulation, these virions start to infect another host cell and start the replication cycle again.
There are no drugs that can prevent maturation and budding process.
The average life span of virus-producing host cells is short, around two days. Each infected cell can produce an average of 250 new HIV virions before failing and dying.
- Yes it is, oral sex can pass HIV.
- Understand more about viral load tests.
- Learn more about the word seropositive.
- Do not use drugs.
- Drugs are the end of the sting. But if you can't stop using it, don't share needles and syringes!
- HIV and AIDS well explained
- A little more about HIV and AIDS
- The worst symptom of HIV is prejudice - Cheesy? Cliche? Perhaps. Unfortunately it is a truth that I wish I could cancel or forget.
- HIV and AIDS, some symptoms and signs
- Here is the way to return to the beginning of HIV Positive Blog
- Arts E, Hazuda D. HIV-1 Antiretroviral Drug Therapy. Cold Spring Harb Perspect Med. 2012;2(4):a007161. DOI:10.1101/Csh Perspect.a007161
- Murray J, Kelleher A, Cooper D. Timing of the Components of the HIV Life Cycle in Productively Infected CD4 + T Cells in a Population of HIV-Infected Individuals. J Virol. 2011;85(20):10798–805. DOI:10.1128/JVI.05095-11